Article
Genetic variation in adipokine genes and risk of colorectal cancer.
European journal of endocrinology - 1 Jun 2009
Pechlivanis Sonali, Bermejo Justo Lorenzo, Pardini Barbara, Naccarati Alessio, Vodickova Ludmila, Novotny Jan, Hemminki Kari, Vodicka Pavel, Försti Asta
Abstract excerpt
OBJECTIVE: Obesity has been related to an increased risk of colorectal cancer (CRC). Adipokines produced by the adipose tissue are directly linked to obesity and may thus contribute to the pathogenesis of CRC. We hypothesized that potentially functional polymorphisms in the adipokine genes leptin (LEP), leptin receptor (LEPR), resistin (RETN), and adiponectin (ADIPOQ) may be associated with CRC. DESIGN AND...
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