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Article

Evidence that senescent human prostate epithelial cells enhance tumorigenicity: cell fusion as a potential mechanism and inhibition by p16INK4a and hTERT.

International journal of cancer - 1 Apr 2008

Bhatia Bobby, Multani Asha S, Patrawala Lubna, Chen Xin, Calhoun-Davis Tammy, Zhou Jianjun, Schroeder Lisa, Schneider-Broussard Robin, Shen Jianjun, Pathak Sen, Chang Sandy, Tang Dean G

Abstract excerpt

Normal human prostate (NHP) epithelial cells undergo senescence in vitro and in vivo but the potential role of senescent NHP cells in prostate tumorigenesis remain unclear. Here we show that senescent NHP cells enhance the in vivo tumorigenicity of low-tumorigenic LNCaP prostate cancer and low/non-tumorigenic subset of cells (called L cells) isolated from multiple bulk-cultured prostate (and other) cancer cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18059027
DOI: 10.1002/ijc.23222

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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