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Article

Prostate Cancer Cells with Stem Cell Characteristics Reconstitute the Original Human Tumor <i>In vivo</i>

15 May 2007

Abstract excerpt

Cancer may arise from a cancer stem/progenitor cell that shares characteristics with its normal counterpart. We report the reconstitution of the original human prostate cancer specimen from epithelial cell lines (termed HPET for human prostate epithelial/hTERT) derived from this sample. These tumors can be described in terms of Gleason score, a classification not applied to any of the transgenic mouse models...

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PMID: 17510410
DOI: 10.1158/0008-5472.can-06-4608

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