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Article

High prevalence of the CYP2B6 516G-->T(*6) variant and effect on the population pharmacokinetics of efavirenz in HIV/AIDS outpatients in Zimbabwe.

European journal of clinical pharmacology - 1 Apr 2008

Nyakutira Christopher, Röshammar Daniel, Chigutsa Emmanuel, Chonzi Prosper, Ashton Michael, Nhachi Charles, Masimirembwa Collen

Abstract excerpt

OBJECTIVE: The study sought to investigate the relationship between efavirenz exposure and the CYP2B6 516G-->T(*6) genotype in HIV/AIDS outpatients, using pharmacokinetic modelling and simulation. METHODS: Blood samples where obtained from 74 outpatients treated with a combination regimen including 600 mg efavirenz daily for a duration of at least 3 weeks at clinics in Harare, Zimbabwe. The subjects were...

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Identifiers

PMID: 18057928
DOI: 10.1007/s00228-007-0412-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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