Article
A developmental cycle masks output from the circadian oscillator under conditions of choline deficiency in Neurospora.
Proceedings of the National Academy of Sciences of the United States of America - 11 Dec 2007
Shi Mi, Larrondo Luis F, Loros Jennifer J, Dunlap Jay C
Abstract excerpt
In Neurospora, metabolic oscillators coexist with the circadian transcriptional/translational feedback loop governed by the FRQ (Frequency) and WC (White Collar) proteins. One of these, a choline deficiency oscillator (CDO) observed in chol-1 mutants grown under choline starvation, drives an uncompensated long-period developmental cycle ( approximately 60-120 h). To assess possible contributions of this metabolic...
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