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Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progression

3 Dec 2007

Abstract excerpt

Elevated expression and activation of the focal adhesion kinase (FAK) occurs in a large proportion of human breast cancers. Although several studies have implicated FAK as an important signaling molecule in cell culture systems, evidence supporting a role for FAK in mammary tumor progression is lacking. To directly assess the role of FAK in this process, we have used the Cre/loxP recombination system to disrupt...

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PMID: 18056629
DOI: 10.1073/pnas.0710091104

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