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Article

Distinct FAK activities determine progenitor and mammary stem cell characteristics.

Cancer research - 1 Sept 2013

Luo Ming, Zhao Xiaofeng, Chen Song, Liu Suling, Wicha Max S, Guan Jun-Lin

Abstract excerpt

Mammary stem cells (MaSC) and progenitor cells are important for mammary gland development and maintenance and may give rise to mammary cancer stem cells (MaCSC). Yet, there remains limited understanding of how these cells contribute to tumorigenesis. Here, we show that conditional deletion of focal adhesion kinase (FAK) in embryonic mammary epithelial cells (MaEC) decreases luminal progenitors and basal MaSCs,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mammary Glands, Animal

Share to Mammary Neoplasms, Experimental

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Source

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Identifiers

PMID: 23832665
DOI: 10.1158/0008-5472.CAN-13-1351
PMCID: PMC3766468

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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