Article
Genetic alterations in the tyrosine kinase transcriptome of human cancer cell lines.
Cancer research - 1 Dec 2007
Ruhe Jens E, Streit Sylvia, Hart Stefan, Wong Chee-Hong, Specht Katja, Knyazev Pjotr, Knyazeva Tatjana, Tay Liang Seah, Loo Hooi Linn, Foo Priscilla, Wong Winnie, Pok Sharon, Lim Shu Jing, Ong Huimin, Luo Ming, Ho Han Kiat, Peng Kaitian, Lee Tze Chuen, Bezler Martin, Mann Christian, Gaertner Silvia, Hoefler Heinz, Iacobelli Stefano, Peter Stephan, Tay Alice, Brenner Sydney, Venkatesh Byrappa, Ullrich Axel
Abstract excerpt
Protein tyrosine kinases (PTKs) play a critical role in the manifestation of cancer cell properties, and respective signaling mechanisms have been studied extensively on immortalized tumor cells. To characterize and analyze commonly used cancer cell lines with regard to variations in the primary structure of all expressed PTKs, we conducted a cDNA-based sequence analysis of the entire tyrosine kinase...
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