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Article

The Different Tactics of Foot-and-Mouth Disease Virus to Evade Innate Immunity

12 Nov 2018

Abstract excerpt

Like all pathogens, foot-and-mouth disease virus (FMDV) is recognized by the immune system inducing a heightened immune response mainly mediated by type I and type III interferons (IFNs). To overcome the strong antiviral response induced by these cytokines, FMDV has evolved many strategies exploiting each region of its small RNA genome. These include: a) inhibition of IFN induction at the transcriptional and...

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PMID: 30483224
DOI: 10.3389/fmicb.2018.02644

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