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Telithromycin and Quinupristin-Dalfopristin Induce Delayed Death in Plasmodium falciparum

4 Dec 2007

Abstract excerpt

Antibacterial agents are used in malaria therapy due to their effect on two prokaryote organelles, the mitochondrion and the apicoplast. We demonstrate here that the ribosome-blocking antibiotics telithromycin and quinupristin-dalfopristin, but not linezolid, inhibit the growth of Plasmodium falciparum. Both drugs induce delayed death in the parasite, suggesting that their effect involves the impairment of...

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PMID: 18056275
DOI: 10.1128/aac.00892-07

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