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Article

Naphthoimidazoles promote different death phenotypes in Trypanosoma cruzi.

Parasitology - 1 Apr 2009

Menna-Barreto R F S, Corrêa J R, Cascabulho C M, Fernandes M C, Pinto A V, Soares M J, De Castro S L

Abstract excerpt

SUMMARY: In a screening of 65 derivatives of natural quinones using bloodstream trypomastigotes of Trypanosoma cruzi, the 3 naphthoimidazoles derived from beta-lapachone - N1, N2 and N3--were selected as the most active. Investigation of their mode of action led to the characterization of mitochondrion, reservosomes and DNA as their main targets, and stimulated further studies on death pathways. Ultrastructural...

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PMID: 19281638
DOI: 10.1017/S0031182009005745

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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