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Article

Cloning and characterization of a gene affecting the methicillin resistance level and the autolysis rate in Staphylococcus aureus

1 Aug 1994

Abstract excerpt

Tn918 mutagenesis of a high-level methicillin-resistant Staphylococcus aureus (methicillin MIC, 800 micrograms/ml) led to the isolation of a low-resistance mutant. The Tn918 insert was transferred back to the parent to produce strain SRM563 (methicillin MIC, 12.5 micrograms/ml), which showed heterogeneous resistance. Twenty-two clinical isolates of methicillin-resistant S. aureus were transformed with DNA of...

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PMID: 8051012
DOI: 10.1128/jb.176.16.4993-5000.1994

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