Article
Pilot study of neoadjuvant treatment with erlotinib in nonmetastatic head and neck squamous cell carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Dec 2007
Thomas Fabienne, Rochaix Philippe, Benlyazid Adil, Sarini Jérôme, Rives Michel, Lefebvre Jean Louis, Allal Ben C, Courbon Frédéric, Chatelut Etienne, Delord Jean-Pierre
Abstract excerpt
PURPOSE: To determine the safety and efficacy of erlotinib given as neoadjuvant treatment in patients with head and neck squamous cell carcinoma (HNSCC). Further objectives were to identify markers of response to erlotinib and to assess the pharmacodynamic effects of erlotinib in tumor cells. EXPERIMENTAL DESIGN: Patients with locally advanced nonmetastatic HNSCC were treated with erlotinib 150 mg daily pending...
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