Article
The amino acids involved in the distinct carbohydrate specificities between macrophage galactose-type C-type lectins 1 and 2 (CD301a and b) of mice.
Biochimica et biophysica acta - 1 Feb 2008
Oo-Puthinan Sarawut, Maenuma Keisuke, Sakakura Masayoshi, Denda-Nagai Kaori, Tsuiji Makoto, Shimada Ichio, Nakamura-Tsuruta Sachiko, Hirabayashi Jun, Bovin Nicolai V, Irimura Tatsuro
Abstract excerpt
Binding specificities of mouse macrophage galactose-type C-type lectin 1 (MGL1/CD301a) and 2 (MGL2/CD301b) toward various oligosaccharides were compared by frontal affinity chromatography. MGL1 preferentially bound oligosaccharides containing Lewis(X) (Le(X)) trisaccharides among 111 oligosaccharides tested, whereas MGL2 preferentially bound globoside Gb4. The important amino acids for the preferential bindings...
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