Endothelial Sensitivity to Pro-Fibrotic Signals Links Systemic exposure to Pulmonary Fibrosis

Abstract excerpt

<h4>Summary</h4> Pulmonary fibrosis (PF) is a life-threatening condition characterised by excessive extracellular matrix deposition and tissue scarring. While much of PF research has focused on alveolar epithelial cells and fibroblasts, endothelial cells have emerged as active contributors to the disease initiation, especially in the context of systemic exposure to pro-fibrotic substances. Here, we investigate ea...

Topics

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• Connective Tissue Diseases
• Connective Tissue Growth Factor Research
• Disease Management
• Extracellular Matrix Proteins
• Fibroblast Growth Factor Research
• Fibrosis
• Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
• Wound Healing and Treatments

Identifiers and source

Literature Corpus work

6d1eeca6-4280-501b-a580-d10ca509e297

DOI

10.1101/2025.01.02.631148