Article
Antibodies to several citrullinated antigens are enriched in the joints of rheumatoid arthritis patients.
Arthritis and rheumatism - 1 Jan 2010
Snir Omri, Widhe Mona, Hermansson Monika, von Spee Caroline, Lindberg Johan, Hensen Sanne, Lundberg Karin, Engström Ake, Venables Patrick J W, Toes René E M, Holmdahl Rikard, Klareskog Lars, Malmström Vivianne
Abstract excerpt
OBJECTIVE: High titers of specific anti-citrullinated protein antibodies (ACPAs) are frequently present in the serum of rheumatoid arthritis (RA) patients, but their presence in synovial fluid is less well characterized. The purpose of this study was to compare the levels of antibody to 4 well-defined citrullinated candidate RA autoantigens in serum and synovial fluid and to determine whether antibodies to one...
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