Article
Coding and non-coding polymorphisms in alcohol dehydrogenase alters protein expression and alcohol-associated erythema.
The Journal of investigative dermatology - 1 Mar 2008
Pershing Lynn K, Chen Yuexian, Tkachuk Ariana N, Rausch Holly L, Petelenz-Rubin Kasia, Corlett Judy L, Hobbs Maurine R
Abstract excerpt
Ethanol (EtOH), isopropyl alcohol (IPA), and propylene glycol (PG) increase topical drug delivery, but are sometimes associated with erythema. A potential genetic basis for alcohol-associated erythema was investigated as the function of polymorphisms in coding and non-coding regions of class IB alcohol dehydrogenase (ADHIB) and evaluated for altered gene expression in vitro and metabolic activity in vivo via...
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