Article
Incorporation of the genetic control of alcohol dehydrogenase into a physiologically based pharmacokinetic model for ethanol in humans.
Toxicological sciences : an official journal of the Society of Toxicology - 1 Mar 2004
Sultatos Lester G, Pastino Gina M, Rosenfeld Clint A, Flynn Edward J
Abstract excerpt
The assessment of the variability of human responses to foreign chemicals is an important step in characterizing the public health risks posed by nontherapeutic hazardous chemicals and the risk of encountering adverse reactions with drugs. Of the many sources of interindividual variability in chemical response identified to date, hereditary factors are some of the least understood. Physiologically based...
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