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Article

Genotypes in matrix metalloproteinase 9 are a risk factor for COPD.

International journal of chronic obstructive pulmonary disease - 1 Jan 2006

Tesfaigzi Yohannes, Myers Orrin B, Stidley Christine A, Schwalm Kurt, Picchi Maria, Crowell Richard E, Gilliland Frank D, Belinsky Steven A

Abstract excerpt

A growing body of evidence indicates that matrix metalloproteinases (MMPs) play a role in the pathogenesis of COPD. Therefore, we conducted a candidate gene association study of 4 promoter polymorphisms that are known to modify expression levels of the MMP-1, MMP-2, and MMP-9 genes and a Gln279Arg polymorphism in exon 6 of MMP-9 that modifies the substrate-binding region. We examined the association of each...

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Identifiers

PMID: 18046864
DOI: 10.2147/copd.2006.1.3.267
PMCID: PMC2707156

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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