Article
A functional polymorphism at the miR‑491‑5p binding site in the 3'‑untranslated region of the MMP‑9 gene increases the risk of developing ventilator‑associated pneumonia.
International journal of molecular medicine - 1 Dec 2021
Meng Weimin, Cao Xiuting, Sun Wengqing, Zheng Liheng, Fan Bingdong, Zhou Shengjing, Liu Hongjuan, Wang Hua, Wang Wenxin, Liu Xiang
Abstract excerpt
Matrix metalloproteinase (MMP)‑9 is associated with the severity of ventilator‑associated pneumonia (VAP), while an rs1056629 SNP located in the 3'‑untranslated region (UTR) of MMP‑9 affects the microRNA (miRNA/miR)‑491‑mediated regulation of MMP‑9 expression. In the present study, the effect of rs1056629 on the development of VAP in patients with chronic obstructive pulmonary disease (COPD) was investigated....
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