Article
Matrix Metalloproteinase-9 (279R/Q) Polymorphism is Associated with Clinical Severity and Airflow Limitation in Tunisian Patients with Chronic Obstructive Pulmonary Disease.
Molecular diagnosis & therapy - 1 Dec 2015
Bchir Sarra, Nasr Hela Ben, Hakim Imen Rekik, Anes Amel Ben, Yacoub Saloua, Garrouch Abdelhamid, Benzarti Mohamed, Bauvois Brigitte, Tabka Zouhair, Chahed Karim
Abstract excerpt
BACKGROUND: The aim of this study was to investigate the role of matrix metalloproteinase-9 (MMP-9) C-1562T and 279R/Q (836G>A) polymorphisms in the development of chronic obstructive pulmonary disease (COPD) in Tunisians and to determine their impact on disease progression and airflow obstruction. METHODS: Pulmonary functional tests were evaluated by body plethysmography. MMP-9 genotypes were determined in...
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