Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Predicting HIV-1 transmission and antibody neutralization efficacy in vivo from stoichiometric parameters.

PLoS pathogens - 1 May 2017

Brandenberg Oliver F, Magnus Carsten, Rusert Peter, Günthard Huldrych F, Regoes Roland R, Trkola Alexandra

Abstract excerpt

The potential of broadly neutralizing antibodies targeting the HIV-1 envelope trimer to prevent HIV-1 transmission has opened new avenues for therapies and vaccines. However, their implementation remains challenging and would profit from a deepened mechanistic understanding of HIV-antibody interactions and the mucosal transmission process. In this study we experimentally determined stoichiometric parameters of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Neutralizing
Share to Genes, Reporter

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HIV Antibodies

Share to HIV Infections

Share to Immunization, Passive

Share to Models, Theoretical

Share to Mucous Membrane

Share to Virion

Source

Open in PubMed Open full text

Identifiers

PMID: 28472201
DOI: 10.1371/journal.ppat.1006313
PMCID: PMC5417720

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Predicting HIV-1 transmission and antibody neutralization efficacy in vivo from stoichiometric parameters.PMID 28472201Read ↗

HIV-1 Neutralization: Mechanisms and Relevance to Vaccine DesignSemantic proximity Read ↗

Modeling how many envelope glycoprotein trimers per virion participate in human immunodeficiency virus infectivity and its neutralization by antibodySemantic proximity Read ↗

Host-pathogen coevolution and the emergence of broadly neutralizing antibodies in chronic infectionsSemantic proximity Read ↗

The molecular reach of antibodies crucially underpins their viral neutralisation capacitySemantic proximity Read ↗

Barriers in recipient partners cause frequent transient HIV infections and explain transmission risk under viral suppressionSemantic proximity Read ↗

Optimizing clinical dosing of combination broadly neutralizing antibodies for HIV preventionSemantic proximity Read ↗

Optimizing clinical dosing of combination broadly neutralizing antibodies for HIV preventionSemantic proximity Read ↗

HIV-1 resistance to neutralizing antibodies: Determination of antibody concentrations leading to escape mutant evolution.Semantic proximity Read ↗

Modeling quantifies in vivo neutralization, Fc-mediated killing, and resistance in human clinical trials of five anti-HIV broadly neutralizing antibodiesSemantic proximity Read ↗

Binding of inferred germline precursors of broadly neutralizing HIV-1 antibodies to native-like envelope trimersSemantic proximity Read ↗

Which Antibody Functions are Important for an HIV Vaccine?Semantic proximity Read ↗

Mechanism for evolution of diverse autologous antibodies upon broadly neutralizing antibody therapy of people with HIVSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.