Article
Interleukin (IL)-18 polymorphism 133C/G is associated with severe respiratory syncytial virus infection.
The Pediatric infectious disease journal - 1 Dec 2007
Puthothu Beena, Krueger Marcus, Forster Johannes, Heinze Jessica, Weckmann Markus, Heinzmann Andrea
Abstract excerpt
BACKGROUND: Respiratory syncytial virus (RSV) is a major cause of bronchiolitis in infants. During the course of RSV infection, predominant T helper cell (TH) 2 response is associated with disease progression, whereas predominant TH1 reaction provides convalescence. Interleukin (IL)-18 plays an important role in adjusting the TH1/TH2 immune response to viral infections. Thus, we tested the hypothesis that...
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