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Article

Glucocorticoid receptor is required for skin barrier competence.

Endocrinology - 1 Mar 2008

Bayo Pilar, Sanchis Ana, Bravo Ana, Cascallana Jose Luis, Buder Katrin, Tuckermann Jan, Schütz Günther, Pérez Paloma

Abstract excerpt

To investigate the contribution of the glucocorticoid receptor (GR) in skin development and the mechanisms underlying this function, we have analyzed two mouse models in which GR has been functionally inactivated: the knockout GR(-/-) mice and the dimerization mutant GR(dim/dim) that mediates defective DNA binding-dependent transcription. Because GR null mice die perinatally, we evaluated skin architecture of...

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Share to Cell Membrane Permeability
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18039792
DOI: 10.1210/en.2007-0814

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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