Article
High prevalence of respiratory ciliary dysfunction in congenital heart disease patients with heterotaxy.
Circulation - 8 May 2012
Nakhleh Nader, Francis Richard, Giese Rachel A, Tian Xin, Li You, Zariwala Maimoona A, Yagi Hisato, Khalifa Omar, Kureshi Safina, Chatterjee Bishwanath, Sabol Steven L, Swisher Matthew, Connelly Patricia S, Daniels Mathew P, Srinivasan Ashok, Kuehl Karen, Kravitz Nadav, Burns Kimberlie, Sami Iman, Omran Heymut, Barmada Michael, Olivier Kenneth, Chawla Kunal K, Leigh Margaret, Jonas Richard, Knowles Michael, Leatherbury Linda, Lo Cecilia W
Abstract excerpt
BACKGROUND: Patients with congenital heart disease (CHD) and heterotaxy show high postsurgical morbidity/mortality, with some developing respiratory complications. Although this finding is often attributed to the CHD, airway clearance and left-right patterning both require motile cilia function. Thus, airway ciliary dysfunction (CD) similar to that of primary ciliary dyskinesia (PCD) may contribute to increased...
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