Article
Peptidoglycan recognition protein-S (PGRP-S) is upregulated by NF-kappaB.
Neuroscience letters - 10 Jan 2008
Lang Ming-Fei, Schneider Armin, Krüger Carola, Schmid Roland, Dziarski Roman, Schwaninger Markus
Abstract excerpt
Cerebral ischemia triggers inflammation and apoptosis, and the transcription factor NF-kappaB is a key regulator of both events. Here, we report on the induction of the peptidoglycan recognition protein-S (PGRP-S) in a mouse model of cerebral ischemia. Upregulation was reduced if the NF-kappaB subunit RelA was conditionally deleted in the brain. Regulation of PGRP-S transcription by RelA was confirmed in vitro....
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