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Article

Matrix Metalloproteinases Contribute to Brain Damage in Experimental Pneumococcal Meningitis

1 Feb 2000

Abstract excerpt

The present study was performed to evaluate the role of matrix metalloproteinases (MMP) in the pathogenesis of the inflammatory reaction and the development of neuronal injury in a rat model of bacterial meningitis. mRNA encoding specific MMPs (MMP-3, MMP-7, MMP-8, and MMP-9) and the inflammatory cytokine tumor necrosis factor alpha (TNF-alpha) were significantly (P < 0.04) upregulated, compared to the beta-actin...

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PMID: 10639424
DOI: 10.1128/iai.68.2.615-620.2000

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