Article
Frequencies of genetic polymorphisms related to triptans metabolism in chronic migraine.
The journal of headache and pain - 1 Apr 2010
Gentile Giovanna, Missori Serena, Borro Marina, Sebastianelli Alisa, Simmaco Maurizio, Martelletti Paolo
Abstract excerpt
Chronic migraine (CM) prevalence ranges around 1-5%. Most of these patients usually treat their acute attacks with triptans, whose efficacy is extremely variable. A genetic basis for migraine is evident and many susceptibility genes have been described, as well as gene polymorphisms possibly implied in therapy response. Several factors could be involved in the evolution of episodic migraine into a chronic form,...
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