Back to search

Article

Identification of CLDN18 as a potential diagnostic biomarker and therapeutic target for pancreatic cancer based on multiomic analysis

2020-02-29

Abstract excerpt

<title>Abstract</title> <p>Background Claudin 18 (CLDN18) is a transmembrane protein localized in the apical regions to form a tight-junction complex. The expression of CLDN18 was restricted to normal lung and stomach tissues but was aberrantly activated in some types of cancers, and this molecule can serve as a promising target for targeted treatment. Methods The mRNA expression, genetic variations and progno...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
a739fff3-7d22-5c5d-bde6-5c66316659cd
DOI
10.21203/rs.3.rs-15518/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Identification of CLDN18 as a potential diagnostic biomarker and therapeutic target for pancreatic cancer based on multiomic analysisDOI 10.21203/rs.3.rs-15518/v1
Claudin 18.2 is a potential therapeutic target for zolbetuximab in pancreatic ductal adenocarcinomaSemantic proximity
Personalized Medicine in Pancreatic Cancer: The Promise of Biomarkers and Molecular Targeting with Dr. Michael J. PishvaianSemantic proximity
Identification of critical pathways and potential therapeutic targets in Poorly differentiated duodenal papilla adenocarcinomaSemantic proximity
Clinical significance and prospective molecular mechanism of MALAT1 in pancreatic cancer exploration: a comprehensive study based on the GeneChip, GEO, Oncomine, and TCGA databasesSemantic proximity
CLDN6: From Traditional Barrier Function to Emerging Roles in CancersSemantic proximity
Transcriptomic Profiling Identifies DCBLD2 as a Diagnostic and Prognostic Biomarker in Pancreatic Ductal AdenocarcinomaSemantic proximity
High expression of the LAMA3/AC245041.2 gene pair associated with KRAS mutation and poor survival in pancreatic adenocarcinoma: A comprehensive TCGA analysisSemantic proximity
Identification of Claudin-6 as a Molecular Biomarker in Pan-Cancer Through Multiple Omics Integrative AnalysisSemantic proximity
Potential Prognostic Biomarkers of OSBPL Family Genes in Patients with Pancreatic Ductal AdenocarcinomaSemantic proximity
Claudin-18 Splice Variant 2 Is a Pan-Cancer Target Suitable for Therapeutic Antibody DevelopmentSemantic proximity
In Silico Transcriptomic Analysis of the Chloride Intracellular Channels (CLIC) Interactome Identifies a Molecular Panel of Seven Prognostic Markers in Patients with Pancreatic Ductal AdenocarcinomaSemantic proximity
PPP3CB inhibits pancreatic cancer progression via promoting translocation of ATOH8 and further transcriptionally regulating Sp1Semantic proximity
Select a neighboring publication to make it the new centre.