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Apolipoprotein E genotype and alpha-tocopherol modulate amyloid precursor protein metabolism and cell cycle regulation.

Molecular nutrition & food research - 1 Dec 2007

Huebbe Patricia, Schaffer Sebastian, Jofre-Monseny Laia, Boesch-Saadatmandi Christine, Minihane Anne-Marie, Müller Walter E, Eckert Gunter P, Rimbach Gerald

Abstract excerpt

Apolipoprotein E4 (apoE4) genotype is associated with an increased risk for Alzheimer's disease (AD). This is thought to be in part attributable to an impact of apoE genotype on the processing of the transmembrane amyloid precursor protein (APP) thereby contributing to amyloid beta peptide formation in apoE4 carriers, which is a primary patho-physiological feature of AD. As apoE and alpha-tocopherol (alpha-toc)...

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Identifiers

PMID: 18030662
DOI: 10.1002/mnfr.200700194

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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