Article
Wt1 and retinoic acid signaling are essential for stellate cell development and liver morphogenesis.
Developmental biology - 1 Dec 2007
Ijpenberg A, Pérez-Pomares J M, Guadix J A, Carmona R, Portillo-Sánchez V, Macías D, Hohenstein P, Miles C M, Hastie N D, Muñoz-Chápuli R
Abstract excerpt
Previous studies of knock-out mouse embryos have shown that the Wilms' tumor suppressor gene (Wt1) is indispensable for the development of kidneys, gonads, heart, adrenals and spleen. Using OPT (Optical Projection Tomography) we have found a new role for Wt1 in mouse liver development. In the abs...
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