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Sox9 inhibits Activin A to promote biliary maturation and branching morphogenesis

15 Feb 2025

Abstract excerpt

Intrahepatic bile duct (IHBD) development produces a morphologically heterogeneous network of large “ducts” and small “ductules” by adulthood. IHBD formation is closely linked to developmental specification of biliary epithelial cells (BECs) starting as early as E13.5, but mechanisms regulating differential IHBD morphology remain poorly understood. Here, we show that duct and ductule development has distinct...

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PMID: 39955269
DOI: 10.1038/s41467-025-56813-x

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