Article
A novel approach to specific allergy treatment: the recombinant allergen-S-layer fusion protein rSbsC-Bet v 1 matures dendritic cells that prime Th0/Th1 and IL-10-producing regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 2007
Gerstmayr Marianne, Ilk Nicola, Schabussova Irma, Jahn-Schmid Beatrice, Egelseer Eva M, Sleytr Uwe B, Ebner Christof, Bohle Barbara
Abstract excerpt
An ideal vaccine for allergen-specific immunotherapy of type I allergies should display reduced mediator-releasing capacity, induce maturation of APC, and modify the disease-eliciting Th2-dominated allergen-specific response to a more physiological response. We have previously shown that rSbsC-Bet v 1, the recombinant fusion protein of a bacterial surface (S-layer) protein of Geobacillus stearothermophilus ATCC...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.