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Article

Genomic comparison of virulent Rickettsia rickettsii Sheila Smith and avirulent Rickettsia rickettsii Iowa.

Infection and immunity - 1 Feb 2008

Ellison Damon W, Clark Tina R, Sturdevant Daniel E, Virtaneva Kimmo, Porcella Stephen F, Hackstadt Ted

Abstract excerpt

Rickettsia rickettsii is an obligate intracellular pathogen that is the causative agent of Rocky Mountain spotted fever. To identify genes involved in the virulence of R. rickettsii, the genome of an avirulent strain, R. rickettsii Iowa, was sequenced and compared to the genome of the virulent strain R. rickettsii Sheila Smith. R. rickettsii Iowa is avirulent in a guinea pig model of infection and displays...

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Identifiers

PMID: 18025092
DOI: 10.1128/IAI.00952-07
PMCID: PMC2223442

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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