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Article

Influence of the tyrosine hydroxylase val81met polymorphism and catechol-O-methyltransferase val158met polymorphism on the antidepressant effect of milnacipran.

Human psychopharmacology - 1 Mar 2008

Yoshida Keizo, Higuchi Hisashi, Takahashi Hitoshi, Kamata Mitsuhiro, Sato Kazuhiro, Inoue Kazuyuki, Suzuki Toshio, Itoh Kunihiko, Ozaki Norio

Abstract excerpt

OBJECTIVE: Genetic polymorphisms of the noradrenergic pathway can be factors to predict the effect of antidepressants when their pharmacological mechanisms of action include the noradrenergic system. The purpose of the present study was to determine whether the tyrosine hydroxylase (TH) val81met...

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Source

Identifiers

PMID: 18023073
DOI: 10.1002/hup.907

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18023073-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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