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Article

Structural basis for the reaction mechanism of UDP-glucose pyrophosphorylase.

Molecules and cells - 1 Apr 2010

Kim Hun, Choi Jongkeun, Kim Truc, Lokanath Neratur K, Ha Sung Chul, Suh Se Won, Hwang Hye-Yeon, Kim Kyeong Kyu

Abstract excerpt

UDP-glucose pyrophosphorylases (UGPase; EC 2.7.7.9) catalyze the conversion of UTP and glucose-1-phosphate to UDP-glucose and pyrophosphate and vice versa. Prokaryotic UGPases are distinct from their eukaryotic counterparts and are considered appropriate targets for the development of novel antibacterial agents since their product, UDP-glucose, is indispensable for the biosynthesis of virulence factors such as...

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PMID: 20238176
DOI: 10.1007/s10059-010-0047-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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