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Article

Sugar specificity of bacterial CMP kinases as revealed by crystal structures and mutagenesis of Escherichia coli enzyme.

Journal of molecular biology - 1 Feb 2002

Bertrand Thomas, Briozzo Pierre, Assairi Liliane, Ofiteru Augustin, Bucurenci Nadia, Munier-Lehmann Hélène, Golinelli-Pimpaneau Béatrice, Bârzu Octavian, Gilles Anne-Marie

Abstract excerpt

Bacterial cytidine monophosphate (CMP) kinases are characterised by an insert enlarging their CMP binding domain, and by their particular substrate specificity. Thus, both CMP and 2'-deoxy-CMP (dCMP) are good phosphate acceptors for the CMP kinase from Escherichia coli (E. coli CMPK), whereas eukaryotic UMP/CMP kinases phosphorylate the deoxynucleotides with very low efficiency. Four crystal structures of E. coli...

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PMID: 11827479
DOI: 10.1006/jmbi.2001.5286

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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