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Article

Structure-function relationships of UMP kinases from pyrH mutants of Gram-negative bacteria.

Microbiology (Reading, England) - 1 Jul 2004

Sakamoto Hiroshi, Landais Stéphanie, Evrin Cécile, Laurent-Winter Christine, Bârzu Octavian, Kelln Rod A

Abstract excerpt

Bacterial uridine monophosphate (UMP) kinases are essential enzymes encoded by pyrH genes, and conditional-lethal or other pyrH mutants were analysed with respect to structure-function relationships. A set of thermosensitive pyrH mutants from Escherichia coli was generated and studied, along with already described pyrH mutants from Salmonella enterica serovar Typhimurium. It is shown that Arg-11 and Gly-232 are...

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Identifiers

PMID: 15256558
DOI: 10.1099/mic.0.26996-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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