Article
Riboswitch-dependent gene regulation and its evolution in the plant kingdom.
Genes & development - 15 Nov 2007
Bocobza Samuel, Adato Avital, Mandel Tali, Shapira Michal, Nudler Evgeny, Aharoni Asaph
Abstract excerpt
Riboswitches are natural RNA sensors that affect gene control via their capacity to bind small molecules. Their prevalence in higher eukaryotes is unclear. We discovered a post-transcriptional mechanism in plants that uses a riboswitch to control a metabolic feedback loop through differential processing of the precursor RNA 3' terminus. When cellular thiamin pyrophosphate (TPP) levels rise, metabolite sensing by...
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