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Article

Stem cell factor receptor (c-KIT) codon 816 mutations predict development of bilateral testicular germ-cell tumors.

Cancer research - 15 Nov 2003

Looijenga Leendert H J, de Leeuw Hubert, van Oorschot Monique, van Gurp Ruud J H L M, Stoop Hans, Gillis Ad J M, de Gouveia Brazao Carlos A, Weber Rob F A, Kirkels Wim J, van Dijk Thamar, von Lindern Marieke, Valk Peter, Lajos Geczy, Olah Edit, Nesland Jahn M, Fosså Sophie D, Oosterhuis J Wolter

Abstract excerpt

Testicular germ-cell tumors (TGCTs) of adolescents and adults originate from intratubular germ cell neoplasia (ITGCN), which is composed of the malignant counterparts of embryonal germ cells. ITGCN cells are characterized, among others, by the presence of stem cell factor receptor c-KIT. Once est...

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Identifiers

PMID: 14633689

Genes

KIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-14633689-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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