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Article

XylS-Pm promoter interactions through two helix-turn-helix motifs: identifying XylS residues important for DNA binding and activation.

Journal of molecular biology - 4 Jan 2008

Domínguez-Cuevas Patricia, Marín Patricia, Marqués Silvia, Ramos Juan Luis

Abstract excerpt

The XylS protein is the positive transcription regulator of the TOL plasmid meta-cleavage pathway operon Pm. XylS belongs to the AraC family of transcriptional regulators and exhibits an N-terminal domain involved in effector recognition, and a C-terminal domain, made up of seven alpha-helices conforming two helix-turn-helix DNA-binding domains. alpha-Helix 3 and alpha-helix 6 are the recognition helices. In...

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Source

Identifiers

PMID: 18005985
DOI: 10.1016/j.jmb.2007.10.047

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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XylS-Pm promoter interactions through two helix-turn-helix motifs: identifying XylS residues important for DNA binding and activation.PMID 18005985Read ↗

Mutational analysis of the highly conserved C-terminal residues of the XylS protein, a member of the AraC family of transcriptional regulators.Semantic proximity Read ↗

Mutations leading to constitutive expression from the TOL plasmid meta-cleavage pathway operon are located at the C-terminal end of the positive regulator protein XylS.Semantic proximity Read ↗

Residues 137 and 153 of XylS influence contacts with the C-terminal domain of the RNA polymerase alpha subunit.Semantic proximity Read ↗

Signal-regulator interactions. Genetic analysis of the effector binding site of xylS, the benzoate-activated positive regulator of Pseudomonas TOL plasmid meta-cleavage pathway operon.Semantic proximity Read ↗

The organization of the Pm promoter of the TOL plasmid reflects the structure of its cognate activator protein XylS.Semantic proximity Read ↗

Identification of critical amino-terminal regions of XylS. The positive regulator encoded by the TOL plasmid.Semantic proximity Read ↗

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Residues 137 and 153 at the N terminus of the XylS protein influence the effector profile of this transcriptional regulator and the sigma factor used by RNA polymerase to stimulate transcription from its cognate promoter.Semantic proximity Read ↗

Allosteric regulation within the highly interconnected structural scaffold of AraC/XylS homologs tolerates a wide range of amino acid changes.Semantic proximity Read ↗

A comprehensive alanine scanning mutagenesis of the Escherichia coli transcriptional activator SoxS: identifying amino acids important for DNA binding and transcription activation.Semantic proximity Read ↗

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Transcriptional control by two interacting regulatory proteins: identification of the PtxS binding site at PtxR.Semantic proximity Read ↗

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