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Article

Residues 137 and 153 of XylS influence contacts with the C-terminal domain of the RNA polymerase alpha subunit.

Biochemical and biophysical research communications - 21 Sept 2001

Ruiz R, Ramos J L

Abstract excerpt

XylS and XylS1 are transcriptional regulators that stimulate transcription from the Pm promoter for the meta-cleavage pathway operon for alkylbenzoate degradation. These regulators that differ in five amino acids interact with alpha-CTD domain of RNA polymerase. These interactions take place preferentially through residues 291 in XylS and 289 in XylS1. Substitution at position 137 and 153 in XylS influence the...

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Identifiers

PMID: 11554759
DOI: 10.1006/bbrc.2001.5615

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Residues 137 and 153 of XylS influence contacts with the C-terminal domain of the RNA polymerase alpha subunit.PMID 11554759Read ↗

XylS-Pm promoter interactions through two helix-turn-helix motifs: identifying XylS residues important for DNA binding and activation.Semantic proximity Read ↗

Residues 137 and 153 at the N terminus of the XylS protein influence the effector profile of this transcriptional regulator and the sigma factor used by RNA polymerase to stimulate transcription from its cognate promoter.Semantic proximity Read ↗

Mutations leading to constitutive expression from the TOL plasmid meta-cleavage pathway operon are located at the C-terminal end of the positive regulator protein XylS.Semantic proximity Read ↗

Identification of critical amino-terminal regions of XylS. The positive regulator encoded by the TOL plasmid.Semantic proximity Read ↗

Mutational analysis of the highly conserved C-terminal residues of the XylS protein, a member of the AraC family of transcriptional regulators.Semantic proximity Read ↗

Transcription activation by a variety of AraC/XylS family activators does not depend on the class II-specific activation determinant in the N-terminal domain of the RNA polymerase alpha subunit.Semantic proximity Read ↗

XylS domain interactions can be deduced from intraallelic dominance in double mutants of Pseudomonas putida.Semantic proximity Read ↗

RNA polymerase holoenzymes can share a single transcription start site for the Pm promoter. Critical nucleotides in the -7 to -18 region are needed to select between RNA polymerase with sigma38 or sigma32.Semantic proximity Read ↗

Signal-regulator interactions. Genetic analysis of the effector binding site of xylS, the benzoate-activated positive regulator of Pseudomonas TOL plasmid meta-cleavage pathway operon.Semantic proximity Read ↗

Factors that influence the response of the LysR type transcriptional regulators to aromatic compounds.Semantic proximity Read ↗

Reverse engineering of an aspirin-responsive regulator in bacteriaSemantic proximity Read ↗

The organization of the Pm promoter of the TOL plasmid reflects the structure of its cognate activator protein XylS.Semantic proximity Read ↗

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