Article
Maternal family history of Alzheimer's disease predisposes to reduced brain glucose metabolism.
Proceedings of the National Academy of Sciences of the United States of America - 27 Nov 2007
Mosconi Lisa, Brys Miroslaw, Switalski Remigiusz, Mistur Rachel, Glodzik Lidia, Pirraglia Elizabeth, Tsui Wai, De Santi Susan, de Leon Mony J
Abstract excerpt
Having a parent affected with late-onset Alzheimer's disease (AD) is a risk factor for developing AD among cognitively normal subjects. We examined whether cognitively normal subjects with a parental family history of AD show cerebral metabolic rate of glucose (CMRglc) reductions consistent with AD as compared with those without a family history and whether there are parent gender effects. Forty-nine 50- to...
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