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Article

Association of years to parent's sporadic onset and risk factors with neural integrity and Alzheimer biomarkers.

Neurology - 13 Oct 2020

Arenaza-Urquijo Eider M, Salvadó Gemma, Operto Gregory, Minguillón Carolina, Sánchez-Benavides Gonzalo, Crous-Bou Marta, Grau-Rivera Oriol, Sala-Vila Aleix, Falcón Carles, Suárez-Calvet Marc, Zetterberg Henrik, Blennow Kaj, Gispert Juan Domingo, Molinuevo José Luis

Abstract excerpt

OBJECTIVE: To evaluate the hypothesis that proximity to parental age at onset (AAO) in sporadic Alzheimer disease (AD) is associated with greater AD and neural injury biomarker alterations during midlife and to assess the role of nonmodifiable and modifiable factors. METHODS: This observational study included 290 cognitively unimpaired (CU) participants with a family history (FH) of clinically diagnosed sporadic...

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Identifiers

PMID: 32737076
DOI: 10.1212/WNL.0000000000010527
PMCID: PMC7774330

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