Article
The prognostic value of clonal heterogeneity and quantitative assessment of plasma circulating clonal IG-VDJ sequences at diagnosis in patients with follicular lymphoma.
Oncotarget - 31 Jan 2017
Sarkozy Clémentine, Huet Sarah, Carlton Victoria E H, Fabiani Bettina, Delmer Alain, Jardin Fabrice, Delfau-Larue Marie-Helene, Hacini Maya, Ribrag Vincent, Guidez Stéphanie, Faham Malek, Salles Gilles
Abstract excerpt
Recent advances in next-generation sequencing (NGS) have enabled the quantitation of circulating tumour DNA (ctDNA) encoding the clonal rearranged V(D)J immunoglobulin locus. We aimed to evaluate the clonal heterogeneity of follicular lymphoma (FL) in the tumour and the plasma at diagnosis and to assess the prognostic value of the ctDNA level. Plasma samples at diagnosis were available for 34 patients registered...
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