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Article

Genetics and epigenetics of 1q rearrangements in hematological malignancies

1 Jan 2007

Abstract excerpt

Recently, we and others have described a novel class of chromosome aberrations that involves constitutive heterochromatin on human chromosome 1 (cytogenetic band 1q12). These anomalies are particularly frequent in B cell non-Hodgkins lymphoma (NHL) and multiple myeloma (MM) and, remarkably, almost invariably involve partial or total gain of chromosome 1q (including 1q12 heterochromatin) and the formation of novel...

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PMID: 18000386
DOI: 10.1159/000108316

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