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Article

BMI1, the polycomb-group gene, is recurrently targeted by genomic rearrangements in progressive B-cell leukemia/lymphoma.

Genes, chromosomes & cancer - 1 Oct 2013

Rouhigharabaei Leila, Ferreiro Julio Finalet, Put Natalie, Michaux Lucienne, Tousseyn Thomas, Lefebvre Christine, Gardiner Anne, De Kelver Wim, Demuynck Hilde, Verschuere Johan, Théate Ivan, Vicente Carmen, Vandenberghe Peter, Cools Jan, Wlodarska Iwona

Abstract excerpt

BMI1, a Polycomb-group gene located at 10p12.2, is implicated in the pathogenesis of a variety of tumors. However, the genetic molecular mechanisms underlying its aberrant expression in cancer cells remain largely unknown. In this study, we show that BMI1 is recurrently targeted by chromosomal aberrations in B-cell leukemia/lymphoma. We identified a novel t(10;14)(p12;q32)/IGH-BMI1 rearrangement and its IGL...

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Source

Identifiers

PMID: 23873701
DOI: 10.1002/gcc.22088

Genes

BMI1
IGH
IGL
NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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