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Article

Evidence of an epigenetic origin for high-risk 1q21 copy number aberrations in multiple myeloma

6 May 2015

Abstract excerpt

Multiple myeloma is a B-cell malignancy stratified in part by cytogenetic abnormalities, including the high-risk copy number aberrations (CNAs) of +1q21 and 17p(-). To investigate the relationship between 1q21 CNAs and DNA hypomethylation of the 1q12 pericentromeric heterochromatin, we treated in vitro peripheral blood cultures of 5 patients with balanced constitutional rearrangements of 1q12 and 5 controls with...

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PMID: 25943786
DOI: 10.1182/blood-2015-03-632075

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