Article
Ovulatory response to treatment of polycystic ovary syndrome is associated with a polymorphism in the STK11 gene.
The Journal of clinical endocrinology and metabolism - 1 Mar 2008
Legro Richard S, Barnhart Huiman X, Schlaff William D, Carr Bruce R, Diamond Michael P, Carson Sandra A, Steinkampf Michael P, Coutifaris Christos, McGovern Peter G, Cataldo Nicholas A, Gosman Gabriella G, Nestler John E, Giudice Linda C, Ewens Kathryn G, Spielman Richard S, Leppert Phyllis C, Myers Evan R
Abstract excerpt
CONTEXT: Clomiphene and insulin sensitizers such as metformin are used to induce ovulation in polycystic ovary syndrome (PCOS), but the ovulatory response is variable, and the causes of this variation are poorly understood. OBJECTIVE: Our objective was to identify predictive genetic polymorphisms and other determinants of ovulatory response. DESIGN: This was a substudy of a multicenter randomized clinical trial....
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