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Article

Phenotype-specific efficacy of letrozole versus clomiphene citrate in polycystic ovary syndrome: a prospective cohort study.

BMC women's health - 13 Mar 2026

Aytemiz Ezgi Aydın, Aslan Batuhan, Kaplan Necati Berk, Aytaç Ruşen, Atabekoğlu Cem, Berker Bülent, Sönmezer Murat, Özmen Batuhan, Şükür Yavuz Emre

Abstract excerpt

OBJECTIVE: To compare the efficacy of letrozole (LT) versus clomiphene citrate (CC) for ovulation induction (OI) in women with polycystic ovary syndrome (PCOS), with emphasis on phenotypic variation and hyperandrogenism severity. METHODS: In this prospective cohort study, 207 infertile women with PCOS diagnosed by modified Rotterdam criteria were treated with escalating doses of LT (n = 103) or CC (n = 104)....

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Identifiers

PMID: 41826916
DOI: 10.1186/s12905-026-04403-4
PMCID: PMC13101089

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